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Dose increases are typically gradual to reduce stomach effects and avoid overshooting what the person can tolerate

This selectivity is both the appeal and the limitation

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It usually takes 16 to 20 weeks to reach the full 2.4 mg of semaglutide

The construct design supports expression of the GSH1 ORF under control of the TEF1 promoter, while a counter-selectable marker is expressed under control of the GSH-regulated pGSH1