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95% CI 0.101.60, I2 0%

68 However, in a population using GLP-1 RAs for obesity management without history of diabetes, increased risk of pancreatitis associated with the GLP-1 RAs was found compared to bupropion-naltrexone (HR 9.1, 95%CI 1.2566.0) suggesting the risk benefit ratio of these medications is influenced by underlying disease state

Semaglutide was associated with a significantly lower risk of opioid overdose after 1 year compared with the other medications, with hazard ratios ranging from 0.32 (95% confidence interval, 0.12-0.89) to 0.58 (95% confidence interval, 0.38-0.87)