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An estimated 3.8 billion people under the age of 50 worldwide have an HSV-1 infection

Other SUMO-deconjugating enzymes such as human sentrin-specific proteases, i.e., SENP3 and SENP5, were reported to localize to the mitochondria, playing a role on mitochondrial fission and mitophagy 87,88

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Gla residues are usually involved in binding calcium, and are essential for the biological activity of all known Gla proteins