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J Neurochem 104:113123 Czeredys M, Mysiorek C, Kulikova N, Samluk L, Berezowski V, Cecchelli R, Nalecz KA (2008) A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the bloodbrain barrier

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The primary evidence-based interventions are fluid, gradually increased soluble fiber, physical activity, and osmotic laxatives when needed, in consultation with the prescribing clinician