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Exogenous administration of FGF21 in DIO in mice show virtually no beneficial effects on glucose tolerance and lipid metabolism, suggesting that the obesity state is FGF21-resistant (240)

Gastrointestinal side effects frequently contribute to tiredness

Conditions Commonly Supported Hashimotos & Graves disease Rheumatoid arthritis & psoriatic arthritis Lupus (SLE) & Sjgrens syndrome Celiac disease, Crohns disease, ulcerative colitis Mast Cell Activation Syndrome (MCAS) Chronic fatigue & immune deficiency patterns Chronic viral infections (EBV, long-haul viral patterns) Lyme disease & tick-borne co-infections Mold illness & environmentally triggered immune suppression Eczema, psoriasis, chronic hives Our Root-Cause Approach Immune and autoimmune disorders rarely come from a single cause

At standard doses of 100 mcg or below, cortisol and prolactin elevations are generally minimal

People specifically looking to increase testosterone may find greater benefits from TRT

Wilson SK, Delk JR II