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The activation function 1 (AF1, residues 142485) in the NTD is constitutively active 20 , whereas the activation function 2 (AF2), a hydrophobic surface composed of helices 3, 4, and 12 located in the LBD, is ligand dependent 21

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I wanted to measure incretins in unfasted mouse plasma (i.e., mice were free-living, and not specifically fasted or stimulated with glucose, food, etc

These data reveal that cagrilintide has an amylin-like binding mode but, compared to other peptides, induces distinct conformational dynamics at calcitonin-family receptors that could contribute to its clinical efficacy