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Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)

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, 30-40

For both types of cytotoxic lymphocytes the actual killing process involves two major mechanisms, i.e., release of a membrane pore-forming protein named perforin from granules, leading to osmotic lysis of target cells, and release of lymphotoxin which activates enzymes in the target cell to cleave DNA in the nucleus

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