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However, the role of epigenetic mechanisms in the pathogenesis of Graves disease has not yet been elucidated

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This observation is the main scientific basis for believing any mucosal route (including nasal) could work, but it is an inference, not a measurement

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10.4239/wjd.v14.i9.1349 112 SweetwyneM

"There are many options for patients." She adds that the authors are joining with the American Academy of Ophthalmology in recommending a post-marketing survey to more accurately assess the number of patients receiving these drugs who experience an adverse ocular reaction