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doi: 10.1016/j.biomaterials.2021.121110

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This response is characterised by upregulation of several cytoprotective and detoxification genes, including ferritin, GSH- S -reductase (GSR), GST, GCLM, and GCLC, phase-I drug oxidation enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), MRP, and heme oxygenase-1 (HO-1) [78, 79]

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Pernicious Anemia: Parenteral vitamin B 12 is the recommended treatment and will be required for the remainder of the patient's life