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Acta Pharmacol Sin (2020) 41(4):56171

Ferritin upregulation inhibits estradiol synthesis via the NF-B/iNOS pathway and downregulates the Nrf2/GPX4 pathway, exacerbating ovarian damage (Sze et al., 2022)

CB-839, a GLS inhibitor that blocks the conversion of glutamine into glutamate, reduced the production of R-2-HG in AML cell lines and patient tissues harboring IDH1/2 mutations 123

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Reasons to revisit your dosing plan include: Plateau in weight loss Persistent side effects Changes in lifestyle or health status Transitioning between medications or brands Always make adjustments under the supervision of a medical professional