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"In the brain, it's thought to reduce food intake by some element of appetite suppression," says Evan Nadler, MD, MBA , former co-director of the obesity program at Children's National Hospital and current adjunct associate professor at George Washington University

Semaglutide, marketed as Ozempic and Wegovy, works as a single GLP-1 receptor agonist and typically produces weight loss of 15-20% of body weight over 12-18 months