Patients have grown accustomed to using injectables, and doctors feel at ease prescribing them, particularly now that once-weekly formulations that improve adherence are available
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Although these data suggest safety of use, PPIs should be used during pregnancy with medical supervision and only in women with complicated GERD refractory to other therapies
References include Jastreboff et al., New England Journal of Medicine , 2022 (SURMOUNT-1, tirzepatide for obesity), the FDA Zepbound prescribing information, the FDA Drug Shortages list (accessed Q1 2026), Patel et al., Annals of Pharmacotherapy , 2024 (compounded GLP-1 dosing errors), and the U.S
Specifically, taking levothyroxine at bedtime, at least 3 h after the last meal, may be a convenient alternative to the traditional morning dose
