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In a key study, Pogribna et al

Treatment discontinuation was highest with semaglutide 7.2 mg, at RR 3.09, while serious adverse events were comparable to placebo across regimens

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In some specific research protocols, alternatives are used: Sterile water for injection (WFI) , when the entire contents of the vial are used at once and a preservative is not needed Physiological saline (0.9% NaCl) , in some applications requiring an isotonic environment Acidic solvents (e.g

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