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Over the 80-week trial period, participants in the highest 12mg dose group achieved an average weight loss of 28.3% (approximately 70.3 lbs), while the 9mg group lost 25.9% (approximately 64.4 lbs), and the 4mg group lost 19.0% (approximately 47.2 lbs), compared to just 2.2% for the placebo group

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Additionally, GLP-1R, expressed in human kidneys proximal tubular cells, the renal vasculature, the preglomerular vascular smooth muscle cells, and juxtaglomerular cells could directly contribute to these functions