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From a molecular biophysics perspective, nutrition directly impacts the biochemical and mechanical properties of the ACL and muscle tissues

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Because of this origin, it is studied as a potential communicator between mitochondria and the rest of the cell, a role researchers refer to as retrograde mitochondrial signaling

The association of goiter with hypothyroidism is almost diagnostic of this condition, but is also seen in certain syndromes due to defective hormone synthesis or hormone response, as described in Chapter 9

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