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This study represents the first evaluation of a combined immunomodulatory and targeted beta cell-protective approach to delay autoimmune diabetes onset, establishing a preclinical framework for next-generation strategies to halt or prevent type 1 diabetes progression

Joshua Kritzer, an associate professor of chemistry at Tufts University, says the study offers evidence that the stapled peptide approach is worth pursuing and could lead to new drugs that interfere with specific protein interactions

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May 2019;42(5):954-963