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Promotes angiogenesis, helping build new blood vessels that improve oxygen and nutrient delivery where it's needed most
Notably, LEO downregulated ACADM , NDUFB8 , SOD2 , COX4I1 , and SDHB (involved in fatty acid oxidation and ROS detoxification), while concurrently upregulating IDH3A , GPX1, CPT1A, PDK4, and MPC1/2 (critical for TCA cycle flux and pyruvate metabolism)
Under these experimental conditions, G49 reduced body weight in the period 37 days of treatment (Fig
The studies were designed to measure weight loss, not to prescribe a specific nutrition strategy
Exclusion criteria included unreliably extracted data, non-English language studies, books, conference papers, case reports, and articles without full text, and non-original articles like reviews and meta-analyses
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