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In this study, however, one-third of the involved population remained with the starting dose of 3 mg despite the recommendation reported in the summary of product characteristics and only 16% reached the maintenance dose of 14 mg [28]
Lixisenatide not only upregulates eNOS but may also promote VEGF expression, with evidence suggesting that some of its vascular effects may occur independently of GLP-1 receptor activation [114]
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Additionally, clinical trials often involve relatively small sample sizes, which limits both the statistical power and generalizability of their findings