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The vertex (crown) often shows different permeability than the frontal hairline, which may explain why some areas respond differently to topical treatments

Lin Z, Tang Q, Wu W, et al

Signs you're using too high a concentration include persistent redness, increased sensitivity to other products, dryness that doesn't respond to moisturizer, and skin that looks worse rather than better over time

[ref] Related article: Glutamate regulation Regulation of synthesis: The amount of the amino acid cysteine in the cell is the limiting factor for glutathione production in a cell

Gpxs exist in multiple isoforms, with different cellular localization and different substrate specificity (15)