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8 Regulatory effects of existing MM therapies on the ferroptosis pathway Currently, no drugs directly targeting the ferroptosis pathway have been approved for the treatment of MM

PMID: 15851010

Importantly, this was supported by transcriptomic profiling, which demonstrated significant metformin-induced alterations to a number of mechanisms implicated in the cellular radioresponse, including cell cycle, cell death and survival

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doi: 10.1371/journal.pone.0141159