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Biological Origin and Expression MOTS-c is translated from a short open reading frame (sORF) within the 12S rRNA region of human mitochondrial DNA, making it one of the few peptides produced directly from mitochondrial DNA

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(PubMed) McNulty H, Strain JJ, Hughes CF, Pentieva K, Ward M

107 Studies have shown that improving intestinal mucosal barrier function and regulating inflammatory signaling pathways by inhibiting oxidative stress may help reduce the inflammatory response in UC patients and disrupt the intestinal barrier