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Their work reveals the role of a transporter protein named SLC33A1 in shuttling oxidized glutathione (GSSG) across the ER membrane, a process vital for sustaining the oxidative environment necessary for correct protein folding

Consistent site selection within the same protocol is essential for reproducible pharmacokinetics

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In the human endothelial Ea.hy926 cell line, we demonstrated that intracellular bilirubin (35 pmol mg 1 protein) could be modulated by either extracellular bilirubin uptake, or by up-regulation of heme oxygenase-1, a cellular enzyme related to endogenous bilirubin synthesis

These effects are dose-dependent and typically most pronounced during the initial weeks and after each dose escalation