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The nutraceuticals discussed in the present paper have antioxidative properties and are increasingly used by migraine patients not only due to mild or even a lack of side effects but also because of their effectiveness (decreased frequency of migraine episodes or shortening of an episode duration)

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Considering the utility and safety of GLP-1RAs as existing anti-diabetic remedies (Gilbert et al., 2020) and the advancement of clinical trials of Ex-4 toward PD (Vijiaratnam et al., 2021), it does not seem exaggerated to describe them as promising agents for myelin regeneration and repair

High doses of exogenous glucagon stimulate insulin secretion and reduce insulin clearance in healthy humans

Brodt et al, 2000) and truncated soluble IGF-1R (D'Ambrosio et al, 1996) are two related strategies to block IGF-1R