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To further confirm the involvement of Nrf2, Nrf2 expression was down-regulated by Nrf2 siRNA transfection, which significantly increased the expression of inflammatory factors including IL-6, iNOS, as well as the cartilage matrix degradation factor, MMP13, in chondrocytes treated with metformin

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Intracellular Metabolic Circuits Shape Inter-Species Microbial Interactions

This means that during postnatal development in diseased retinas, greater excretion of GSSG, into extracellular space where it get hydrolyzed, could lead to an increase in the [GSH]/[GSSG] ratio

doi: 10.1002/advs.202406473 486 ZhouY.LiaoM.ZhuC.HuY.TongT.PengX.et al

10.1139/f68-184 56 RubinZ