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Science 281 : 18601863 Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T and Ichijo H (2001) ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

It is prescribed as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) that is considered outside a healthy range

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