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Estimator uses peer-reviewed clinical-trial mean data (SURMOUNT-1, STEP-1, TRIUMPH Phase 2)

Although many mediators are involved in this process, the most important is hyperglycemia itself as well as the generation of advanced glycosylation end products that may trigger reactive oxygen species (ROS) production and mitochondrial dysfunction

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Rare but Serious Side Effects Though uncommon, some side effects can be serious and must not be ignored

& Schwartzberg, P

Long-term cardiovascular outcome data from the SELECT trial showed that semaglutide reduced major adverse cardiovascular events by 20% compared to placebo indicating net cardiovascular protection, not harm