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Sunagawa Y

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Mild to moderate gastrointestinal side effects don't indicate harm and typically signal that the medication is working effectively

122 Interestingly, GLP-1/estrogen demonstrates a promising role in improving ovarian cyclicity in milder PCOS phenotypes with preserved ovulatory function, effectively normalizing cycle irregularities and enhancing reproductive hormonal balance, while, at lower doses, it outperformed other multi-agonists by reducing body weight (by 10%), fat mass (by 50%), and improving glucose metabolism and insulin sensitivity in PCOS models, without causing significant changes in ovarian or uterine parameters