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It is considered the "master antioxidant", more colloquially it is a super anti-rust

This mechanism helps regulate blood sugar but also explains why loose stools or diarrhea emerge as a common dose-dependent side effect

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Furthermore, oxidative stress can impede the nucleoplasmic translocation of pancreaticoduodenal homeobox factor 1 (PDX-1), impair energy metabolism, and reduce insulin production and release (Wu et al., 2016) and damages the cytoskeleton, along with other physiological processes related to insulin signaling

Evidence-based guidance supports polyethylene glycol (PEG) for constipation