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PMCID: PMC6699358

Taken together, these findings demonstrate that oral butyrate suppresses the mTORC1ISR axis both peripherally and centrally, thereby attenuating PBAT-MPs-induced microglial lipotoxicity, neuroinflammation, and cognitive decline via the gutbrain axis

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These studies highlight the therapeutic potential of GLP-1RAs as systemic anti-inflammatory agents, acting through central and peripheral mechanisms

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11 Interestingly, the majority of patients in the European study who were positive for HLA-B*1502 and developed carbamazepine-induced SJS/TEN were of Southeast Asian descent