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Glucagon like peptide-1 receptor expression in the human thyroid gland

The 39-residue sequence carries strategic substitutions at residues critical to each receptor's binding interface, with the goal of achieving balanced potency rather than the imbalanced profile that characterises tirzepatide at GLP-1R

All of these medications regulate appetite, but they differ in FDA indication, hormonal pathways, and metabolic potency

2022;37(18):e146

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Tirzepatide is technically a dual GIP and GLP-1 receptor agonist, but many patients group it with GLP-1 weight-loss injections because it affects the GLP-1 pathway