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The applicant's assertions regarding the substantial clinical improvement criterion are shown in Table 103, previously published as Table 55 of the CY 2026 OPPS/ASC proposed rule (90 FR 33600 and 33601)

This initial phase often involves significant inflammation around the compressed nerve, and many acute cases resolve on their own with rest and basic care

Practical note on titration: tirzepatide titration schedules described in trial and community sources typically step up from 2.5 mg 5 mg 7.5 mg 10 mg 15 mg every 4 weeks