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347,348 Retrospective findings of narrowing small retinal arteries and widening small veins both suggested the development of DKD, 349 and this was later confirmed by a cross-sectional study 350 and several prospective studies

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What are the benefits

Febuxostat (Uloric): this medication was approved by the FDA in February 2009 for treating patients with gout by lowering their uric acid levels

Although its mechanism is not well understood, a randomized, double-blind, placebo-controlled trial showed that it decreased the duration of sickle crisis by 8 h compared to placebo (133 h vs