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The effect of irbesartan seems to be safe also for the patient with CKD (Harada et al., 2016)

Zinman B et al (2015): Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

[DOI] [PubMed] [Google Scholar] 162.Buitrago M., Lorenz K., Maass A.H., Oberdorf-Maass S., Keller U., Schmitteckert E.M., Ivashchenko Y., Lohse M.J., Engelhardt S

The results showed that NAC provided minor improvements in pregnancy and ovulation rates compared to other treatments like metformin when used to treat unexplained infertility

doi:10.1007/s13311-012-0125-x