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Older weight loss medications such as phentermine are available at very low cost but have more limited applications and are typically only used short-term

During this pre-approval stage, those differences matter more than they would for a standard FDA-approved medication sitting on a regular pharmacy shelf

Similarly, severe heart failure or pulmonary edema represents a contraindication or strong precaution, as large amounts of glycine solution may expand intravascular volume and precipitate or worsen congestive heart failure or pulmonary congestion

The FDA has approved certain GLP-1s as a treatment for obesity, defined as someone who has a body mass index (BMI) of 30 or over

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