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Monitoring for adverse effects is essential during the course of treatment to ensure that the patient responds appropriately to the therapy

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J., Lucia M

Mechanistically, metformin may activate Nrf2 through multiple pathways, including AMPK activation, inhibition of GSK-3mediated Nrf2 degradation, and modulation of intracellular redox homeostasis, all of which facilitate Nrf2 nuclear translocation and subsequent induction of downstream antioxidant genes 48,49

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The reactivity of TRi-1 was tested similarly as described above for compound 2