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It is plausible to assume that DHEA-S that arises from first-pass metabolism after oral DHEA administration behaves in a similar manner to endogenous DHEA-S and contributes to the bodys biological reservoir of DHEA, readily converting to DHEA when the need arises

The main distinction comes down to where the injection is delivered: deep into the muscle or into the fatty tissue just beneath the skin

Enzyme induction will have little effect on the metabolism of drugs with a high hepatic extraction ratio (because there is little percentage change in the amount metabolized that can be achieved during a single pass through the liver)

Individual variability is significant

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What will I feel during an IV treatment