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Growth-stimulatory actions of insulin in vitro and in vivo

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The with-DAC version keeps GH levels elevated for days, which does not match how your body normally pulses GH

IGF-1 LR3 and Glucose Metabolism Research In differentiated 3T3-L1 adipocytes, IGF-1 LR3 was used to investigate IGFBP-independent IGF-1R-mediated glucose uptake pathways, with research confirming that its effects on glucose transport are mediated directly through the IGF-1 receptor rather than through IGFBP modulation providing a clean experimental tool for dissecting receptor-specific metabolic signalling

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doi: 10.1016/S0306-4530(03)00152-5 141 ArmakolasAPhilippouAPanteleakouZNezosASourlaAPetrakiCet al