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Key dosing points from the study: Dose range: 200500 mcg per session (individual variation based on severity and body weight) Frequency: 23 sessions per week during the active treatment phase Duration: 48 weeks of active treatment Route: Local subcutaneous injection proximal to the affected joint Concurrent therapy: Most patients continued physical therapy alongside BPC-157 treatment The combination of local administration and physical therapy aligns with the hypothesis that BPC-157 accelerates structural repair while functional loading (exercise) guides proper tissue remodeling

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The pathomechanisms, which are studied in the scope of clinical trials, are supported by the in vivo models

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(2) M2 microglia regulated immunity and the balance between oligodendrogenesis and neurogenesis by secreting IL-4 and IL-10 (83, 84)