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OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911

Contact your GP if you experience: No improvement after 46 weeks of treatment : Whilst neurological symptoms may take longer to resolve, you should notice some improvement in energy levels or general wellbeing within this timeframe

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10.1097/HJH.0000000000003484 [DOI] [PubMed] [Google Scholar] 321.Kataoka, H

Side effect resolution follows a similar timeline to appetite returngradual rather than abrupt

However, the general pattern of acceleration through month 6 followed by gradual slowing toward a plateau remains consistent across populations