JCI Insight
GLP-1 medications work in part by slowing down stomach emptying, leading to increased feelings of fullness
Research has demonstrated that non-diabetic patients using Ozempic can lose an average of 10-15% of their body weight over a year
The right choice depends on what your healthcare professional determines is safe and appropriate for your health history and goals
Prescribing of the compounds must be based upon the professional judgment of the licensed health care provider after considering the patients unique medical condition and factors including body weight, size and overall health status
Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone
