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Whether these effects occur because BPA is directly interacting with the ion channels on bipolar cells themselves 26 or indirectly altering neuronal activity via intracellular pathways and/or non-genomic estrogenic signaling 88 is not known, though our data supports both hypotheses

As estrogen declines, neuronal glucose metabolism becomes measurably impaired, creating an energetic deficit that manifests as cognitive fatigue and memory disruption

2011, National Institutes of Health

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