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Presuming that the putative high-folatelow-vitamin B-12 interaction on serum holoTC and the metabolic markers of vitamin B-12 status is due to excess folic acid, an important consideration is at what level of exposure might these effects become metabolically and clinically relevant
Persistent side effects beyond 2 weeks after a dose increase Transient nausea, mild constipation, and decreased appetite are expected and normal during the 1 to 2 weeks after each dose increase
Look out for signs like tiredness, weakness, or nerve problems
High doses beyond the typical daily requirement are avoided unless necessary, but there is no evidence of harm to the fetus from normal vitamin B therapy
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