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Oncol 11:273, 1992

He also acknowledges the limitations of a post hoc analysis like this, which benefits from knowledge of the outcomes of the primary analysis, although he adds that each of the six components of this studys end point were prespecified, and most were centrally adjudicated

Mechanistically, high expression of BCAT1 reduces the NAD + /NADH ratio, increases mTORC1 activity, and promotes oxidative phosphorylation and nucleotide biosynthesis

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