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Conserved phosphorylation of the intracellular domains of GABA A receptor 2 and 3 subunits by cAMP-dependent protein kinase, cGMP-dependent protein kinase protein kinase C and Ca 2+ /calmodulin type II-dependent protein kinase

It is also linked to cancer-promoting activity and chemoresistance [24]

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The shadow cast by this physical change makes the area look dark, even if the skin pigment itself hasn't changed