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2 The main reported adverse events associated with semaglutide were gastrointestinal including nausea, vomiting, diarrhea, abdominal pain, and constipation

[1] In phase 3 trials, orforglipron produced 12.4% weight loss (27.3 lbs) at 72 weeks less than injectable tirzepatide (20%) but comparable to oral semaglutide

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It reported 10.0% discontinuation for GI symptoms in the semaglutide arm versus 2.0% on placebo with the great majority occurring during the first 20 weeks of dose escalation