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Collectively, our findings demonstrate the pivotal role of TET1 in controlling cancer cell susceptibility to ferroptosis, with particular significance in AML

Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, has shown weight loss exceeding 24% in early trials

GLP1R expression was significantly higher in metastases (Mets), castration-resistant prostate cancer (CRPC), and neuroendocrine prostate cancer (NEPC) samples compared to normal prostate (Figure 1B)

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Although the development of danuglipron was discontinued in 2025 (Pfizer, 2025)