Rigid 14membered macrocyclic lactone enforces preorganized conformation, minimizing entropic loss when binding MetAP2 active site
Although a trend toward reduced HCC risk was observed, this failed to achieve statistical significance in the overall analysis (IRR: 0.82, 95%CI: 0.61-1.11, P = 0.189), possibly reflecting insufficient follow-up duration to capture the full impact on hepatocarcinogenesis
doi: 10.1016/s1097-2765(01)00323-9 266 AnWGKanekalMSimonMCMaltepeEBlagosklonnyMVNeckersLM
Before using this medication, inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding
TCBZ failure and resistance is increasingly being reported in many countries, raising concerns of how to control the disease in the absence of new flukicides and vaccines 6
patients with arterial hypertension and target organ damage, women with a history of gestation-related hypertensive states, young individuals with isolated systolic hypertension, and patients with secondary forms of arterial hypertension
