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Serrapeptase appeared to reduce pain and swelling after an ankle sprain in a recent study, but the study had weaknesses, as we point out in our article about serrapeptase

however, it must be used under medical supervision

It didn't feature heavily in medical school curricula

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By blocking NNMT, 5-Amino-1MQ has been studied for its role in conserving nicotinamide for NAD production while maintaining SAM

However there is little evidence of an active inflammatory response suggesting that this condition is more of a degenerative fasciosis rather than an inflammatory fasciitis