soul trial oral semaglutide cardiovascular outcomes 2024 results (NEJM 2025): led to a 14% ↓ in major CV events vs placebo in T2DM with ASCVD or CKD — no ↑ in serious AEs. #Semaglutide #CardioDiabetes #updatesinmedicine Summary of the main cardiovascular

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46 Semaglutide exposure (AUC 024h and C max after the tenth dose) was not significantly different between patients with and without upper gastrointestinal disease, hence no dose adjustment is required