glutathione molecule Glutathione – The Super Antioxidant:

How it Affects You: Both smoking and air pollutants introduce high amounts of toxins, causing your body to deplete glutathione rapidly to defend itself

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& Perlmutter, D

PMID: 1809108

Additionally, rare deficiencies of glutathione cycle enzymes (gamma-glutamylcysteine ligase, glutathione synthetase, 5-oxoprolinase, and gamma-glutamyl transferase) have all been associated with neuropsychiatric and cognitive impairments, although detailed phenomenological characterization has not been reported